The Role of Oxidative Stress in Spontaneous Abortion and Recurrent Pregnancy Loss: A Systematic Review

@article{Gupta2007TheRO,
  title={The Role of Oxidative Stress in Spontaneous Abortion and Recurrent Pregnancy Loss: A Systematic Review},
  author={Sajal Gupta and Ashok Agarwal and Jashoman Banerjee and Juan G. Alvarez},
  journal={Obstetrical \& Gynecological Survey},
  year={2007},
  volume={62},
  pages={335-347}
}
Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%–50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation. 15%–20% of clinical pregnancies end in spontaneous abortions. Recurrent pregnancy loss is a frustrating clinical problem both for clinicians and patients. Recurrent pregnancy loss affects 0.5%–3% of women in the reproductive age group, and between 50%–60% of recurrent pregnancy losses… 
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Determination of the value of pro-oxidative and antioxidative parameters in patients with sponta-neous abortion can be the indicator of condition of fetoplacental unit and these analyses can be included in the protocol of the rutine perinatal diagnostics.
Oxidative stress in recurrent pregnancy loss women.
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  • Medicine
    Saudi medical journal
  • 2010
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The decrease in NO production and vitamin E is a result of RPL and not a causative factor, as the RPL was without pathological cause, medication, or fibroid presence, and no significant difference was found between the NO/vitamin E ratio in R PL and controls group.
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It is indicated that higher levels of antioxidants such as SOD, CAT, or TAP, and lower levels of oxidative stress markers such as LPO in the endometrial secretions were associated with successful IVF outcome.
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