The Role of Oxidative Stress in Noise-Induced Hearing Loss

@article{Henderson2005TheRO,
  title={The Role of Oxidative Stress in Noise-Induced Hearing Loss},
  author={Donald Henderson and Eric C. Bielefeld and Kelly C. Harris and Bo Hua Hu},
  journal={Ear and Hearing},
  year={2005},
  volume={27},
  pages={1-19}
}
Modern research has provided new insights into the biological mechanisms of noise-induced hearing loss, and with these new insights comes hope for possible prevention or treatment. Underlying the classic set of cochlear pathologies that occur as a result of noise exposure are increased levels of reactive oxygen species (ROS) that play a significant role in noise-induced hair cell death. Both necrotic and apoptotic cell death have been identified in the cochlea. Included in the current review is… 
View on Wolters Kluwer
audioprotesistas.org
770 Citations
Highly Influential Citations
42
Background Citations
324
Methods Citations
7
Results Citations
9

770 Citations

Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling.

Noise Induced Hearing Loss: The Role of Oxidative Stress

It is confirmed that increasing antioxidant levels in the organ of Corti may be an appropriate approach towards understanding NIHL in humans by increasing the endogenous antioxidant response or by administering antioxidant molecules systemically or locally.

Oxidative Stress in Noise-Induced Hearing Loss

The “physiological cell signaling function of ROS” and the concept of “programmed necrosis, necroptosis” are introduced and how these factors may dictate new strategies of translational research and provide promise for direct therapeutic treatment of NIHL are discussed.

Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss

Noise-Induced Neural Degeneration and Therapeutic Effect of Antioxidant Drugs

These antioxidant drugs were effective in preventing or treating noise-induced hearing loss and in combination with other antioxidants, antioxidant drugs showed a strong synergistic effect.

Protective properties of antioxidant drugs in noise-induced hearing loss in the guinea pig

Three molecules with antioxidant properties that have been studied in the laboratory offer almost complete protection against noise-induced hearing loss, and N-L-acetylcysteine and idebenone also significantly reduced the threshold shift and hair cell loss.

Inhibition of Cochlear HMGB1 Expression Attenuates Oxidative Stress and Inflammation in an Experimental Murine Model of Noise-Induced Hearing Loss

Results suggest that inhibition of HMGB1 by neutralization with anti-HMGB1 antibodies prior to noise exposure effectively attenuated oxidative stress and subsequent inflammation and could have potential as a therapy for NIHL.

Role of antioxidant supplementation in preventing noise induced hearing loss

The results indicate that the best protection can be achieved by using antioxidant molecules acting against mitochondrial induced oxidative stress, such as vitamin E and CoQter and the degree of protection depends on the pharmacological properties of the molecules.

Attenuation of noise-induced hearing loss using methylene blue

It is suggested that the amelioration of impaired mitochondrial electron transport and the potentiation of NT-3 expression by treatment with MB have a significant therapeutic value in preventing ROS-mediated sensorineural hearing loss.

Antioxidant Therapy against Oxidative Damage of the Inner Ear: Protection and Preconditioning

The mechanisms underlying antioxidant-associated therapeutic effects and preconditioning in the inner ear are discussed, including the phenomenon of pre-inducing a preventative pathway by subtle stimuli that do not cause permanent hearing damage.
...

References

SHOWING 1-10 OF 114 REFERENCES

Enhancing Intrinsic Cochlear Stress Defenses to Reduce Noise‐Induced Hearing Loss

The results of three different approaches to enhance intrinsic cochlear defense mechanisms against oxidative stress are presented, following application of ALCAR, carbamathione, and a GSH repletion drug D‐methionine (MET), to a model of noise‐induced hearing loss.

Early Elevation of Cochlear Reactive Oxygen Species following Noise Exposure

These ROS measures extend previous results indicating that noise-induced PTS is associated with elevated cochlear ROS production and ROS-mediated injury, and suggests a sustained process of oxidative stress which might be amenable to intervention with chronic antioxidant therapy.

The Protective Effects of Allopurinol and Superoxide Dismutase on Noise-Induced Cochlear Damage

Findings show that SOD-PEG and allopurinol may preserve cochlear sensitivity associated with noise exposure, which suggests that noise-induced damage to the cochlea may be related to the activity of FORs.

Delayed production of free radicals following noise exposure

Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea

Mechanisms of Cell Death in the Injured Auditory System: Otoprotective Strategies

This paper reviews some components of the apoptotic pathways leading to the death of hair cells and auditory induced by growth factor withdrawal or cisplatin intoxication, including the prevention of oxidative stress-induced apoptosis and the activation of caspases and calpains.

Damage and threshold shift resulting from cochlear exposure to Paraquat-generated superoxide

Oxidative DNA damage is associated with intense noise exposure in the rat

Riluzole rescues cochlear sensory cells from acoustic trauma in the guinea-pig

Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea

...