The Role of Oxidative Stress in Noise-Induced Hearing Loss

  title={The Role of Oxidative Stress in Noise-Induced Hearing Loss},
  author={Donald Henderson and Eric C. Bielefeld and Kelly C. Harris and Bo Hua Hu},
  journal={Ear and Hearing},
Modern research has provided new insights into the biological mechanisms of noise-induced hearing loss, and with these new insights comes hope for possible prevention or treatment. Underlying the classic set of cochlear pathologies that occur as a result of noise exposure are increased levels of reactive oxygen species (ROS) that play a significant role in noise-induced hair cell death. Both necrotic and apoptotic cell death have been identified in the cochlea. Included in the current review is… 

Noise Induced Hearing Loss: The Role of Oxidative Stress

It is confirmed that increasing antioxidant levels in the organ of Corti may be an appropriate approach towards understanding NIHL in humans by increasing the endogenous antioxidant response or by administering antioxidant molecules systemically or locally.

Oxidative Stress in Noise-Induced Hearing Loss

The “physiological cell signaling function of ROS” and the concept of “programmed necrosis, necroptosis” are introduced and how these factors may dictate new strategies of translational research and provide promise for direct therapeutic treatment of NIHL are discussed.

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These antioxidant drugs were effective in preventing or treating noise-induced hearing loss and in combination with other antioxidants, antioxidant drugs showed a strong synergistic effect.

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The results indicate that the best protection can be achieved by using antioxidant molecules acting against mitochondrial induced oxidative stress, such as vitamin E and CoQter and the degree of protection depends on the pharmacological properties of the molecules.

Attenuation of noise-induced hearing loss using methylene blue

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The mechanisms underlying antioxidant-associated therapeutic effects and preconditioning in the inner ear are discussed, including the phenomenon of pre-inducing a preventative pathway by subtle stimuli that do not cause permanent hearing damage.



Enhancing Intrinsic Cochlear Stress Defenses to Reduce Noise‐Induced Hearing Loss

The results of three different approaches to enhance intrinsic cochlear defense mechanisms against oxidative stress are presented, following application of ALCAR, carbamathione, and a GSH repletion drug D‐methionine (MET), to a model of noise‐induced hearing loss.

Early Elevation of Cochlear Reactive Oxygen Species following Noise Exposure

These ROS measures extend previous results indicating that noise-induced PTS is associated with elevated cochlear ROS production and ROS-mediated injury, and suggests a sustained process of oxidative stress which might be amenable to intervention with chronic antioxidant therapy.

The Protective Effects of Allopurinol and Superoxide Dismutase on Noise-Induced Cochlear Damage

Findings show that SOD-PEG and allopurinol may preserve cochlear sensitivity associated with noise exposure, which suggests that noise-induced damage to the cochlea may be related to the activity of FORs.

Mechanisms of Cell Death in the Injured Auditory System: Otoprotective Strategies

This paper reviews some components of the apoptotic pathways leading to the death of hair cells and auditory induced by growth factor withdrawal or cisplatin intoxication, including the prevention of oxidative stress-induced apoptosis and the activation of caspases and calpains.