The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure

@inproceedings{Zhou2014TheRO,
  title={The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure},
  author={Shanshan Zhou and Wanqing Sun and Zhiguo Zhang and Yang Zheng},
  booktitle={Oxidative medicine and cellular longevity},
  year={2014}
}
Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal, and mechanical stress and remains a leading cause of death worldwide. The key pathophysiological process leading to HF is cardiac remodeling, a term referring to maladaptation to cardiac stress at the molecular, cellular, tissue, and organ levels. HF and many of the conditions that predispose one to HF are associated with oxidative stress. Increased generation of reactive oxygen species (ROS) in the heart can… CONTINUE READING

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