The Role of Neurotrophins in Major Depressive Disorder.

@article{Jiang2013TheRO,
  title={The Role of Neurotrophins in Major Depressive Disorder.},
  author={Cheng Jiang and Stephen R J Salton},
  journal={Translational neuroscience},
  year={2013},
  volume={4 1},
  pages={46-58}
}
Neurotrophins and other growth factors have been advanced as critical modulators of depressive behavior. Support for this model is based on analyses of knockout and transgenic mouse models, human genetic studies, and screens for gene products that are regulated by depressive behavior and/or antidepressants. Even subtle alteration in the regulated secretion of brain-derived neurotrophic factor (BDNF), for example, due to a single nucleotide polymorphism (SNP)-encoded Val-Met substitution in… CONTINUE READING
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