The Role of Neurotrophins in Major Depressive Disorder.

  title={The Role of Neurotrophins in Major Depressive Disorder.},
  author={Cheng Jiang and Stephen R J Salton},
  journal={Translational neuroscience},
  volume={4 1},
Neurotrophins and other growth factors have been advanced as critical modulators of depressive behavior. Support for this model is based on analyses of knockout and transgenic mouse models, human genetic studies, and screens for gene products that are regulated by depressive behavior and/or antidepressants. Even subtle alteration in the regulated secretion of brain-derived neurotrophic factor (BDNF), for example, due to a single nucleotide polymorphism (SNP)-encoded Val-Met substitution in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 30 extracted citations


Publications referenced by this paper.
Showing 1-10 of 182 references

Involvement of PI 3 K , GSK - 3 beta and PPARgamma in the antidepressantlike effect of folic acid in the forced swimming test in mice

J. Budni, R. LobatoK., +3 authors D. Martin-de-SaavedraM.
J . Psychopharmacol . • 2012

Similar Papers

Loading similar papers…