The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration: In Vitro Studies

@inproceedings{ZivPolat2014TheRO,
  title={The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration: In Vitro Studies},
  author={O Ziv-Polat and Abraham Shahar and Itay Levy and Hadas Skaat and Sara Neuman and Federica Fregnan and Stefano Geuna and Claudia B. Grothe and Kirsten Haastert-Talini and Shlomo Margel},
  booktitle={BioMed research international},
  year={2014}
}
Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes. In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve growth factor (βNGF), glial cell-derived neurotrophic factor (GDNF), and basic fibroblast growth factor (FGF-2). Comparative stability studies of free versus conjugated factors… CONTINUE READING
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