The Role of Neurosteroids and Nongenomic Effects of Progestins in the Ventral Tegmental Area in Mediating Sexual Receptivity of Rodents

@article{Frye2001TheRO,
  title={The Role of Neurosteroids and Nongenomic Effects of Progestins in the Ventral Tegmental Area in Mediating Sexual Receptivity of Rodents},
  author={Cheryl Anne Frye},
  journal={Hormones and Behavior},
  year={2001},
  volume={40},
  pages={226-233}
}
Progesterone (P(4)) in the ventromedial hypothalamus (VMH) and ventral tegmental (VTA) is important for facilitation of lordosis; however, P(4)'s actions in these brain areas are different. Using lordosis in rodents as in vivo experimental models, we have examined the effects progestins exert in the midbrain and hypothalamus. Localization and blocker studies indicate that P(4)'s actions in the VMH require intracellular progestin receptors (PRs) but in the VTA they do not. Progestins that have… CONTINUE READING
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