The Role of Natural Cytotoxicity Receptors in Various Pathologies: Emphasis on Type I Diabetes

@inproceedings{Enk2014TheRO,
  title={The Role of Natural Cytotoxicity Receptors in Various Pathologies: Emphasis on Type I Diabetes},
  author={J. G. van Enk and Ofer Mandelboim},
  booktitle={Front. Immunol.},
  year={2014}
}
Natural killer (NK) cells are innate immune lymphocytes that function mainly as immune sentinels against viral infection and tumorigenesis. NK cell function is governed by inhibitory and activating signals arising from corresponding receptors. A prominent group of activating NK receptors is the natural cytotoxicity receptors (NCRs), which includes NKp30, NKp44, and NKp46. These receptors bind various diverse ligands of pathogenic, tumor, and even self origin. Type 1 diabetes mellitus (T1D) is a… CONTINUE READING
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