The Role of Muscle Stem Cells in Regeneration and Recovery after Denervation: A Review

@article{Wong2019TheRO,
  title={The Role of Muscle Stem Cells in Regeneration and Recovery after Denervation: A Review},
  author={Alvin Wong and Jason H. Pomerantz},
  journal={Plastic and Reconstructive Surgery},
  year={2019},
  volume={143},
  pages={779–788}
}
Background: Skeletal muscle denervation is a complex clinical problem that still lacks a comprehensive solution. Previous studies have suggested that prolonged periods of denervation lead to a decline in the muscle stem cell population, negatively affecting the ability of muscle to regenerate following reinnervation. Recent advances in the understanding of muscle stem cell biology, along with new techniques that increase the ability to identify and manipulate these cells, provide an opportunity… 
View on Wolters Kluwer
ncbi.nlm.nih.gov
5 Citations
Background Citations
1

5 Citations

Citation Type

Citation Type

Mouse models of sarcopenia: classification and evaluation
TLDR
This paper reviews the mouse models that can be used in the study of sarcopenia, including ageing models, genetically engineered models, hindlimb suspension models, chemical induction models, denervation models, and immobilization models; analyses their advantages and disadvantages and application scope; and summarizes the evaluation of sarc Openia in mouse models.
Recent update on craniofacial tissue engineering
TLDR
The results of the studies covered in this review confirm the potential of craniofacial tissue engineering strategies as an alternative to avoid the problems of currently employed techniques and 3D printing advances may allow for fabrication of patient-specific tissue engineered constructs which should improve post-operative esthetic results of reconstruction.
Alternative splicing transitions associate with emerging atrophy phenotype during denervation‐induced skeletal muscle atrophy
TLDR
This study used a rat model of denervated skeletal muscle atrophy and performed RNA‐sequencing to analyze transcriptome profiling of tibialis anterior muscle at multiple time points following denervation to find that AS is a novel mechanism involving muscle atrophia, which is independent changes at the transcript level.
Overview of Methods to Quantify Invasiveness of Surgical Approaches in Orthopedic Surgery—A Scoping Review
TLDR
Owing to their high accuracy and low invasiveness, radiological methods are, in this opinion, the best suited for computational applications optimizing surgical procedures.
Effects of Timing of Nerve Injury and Repair in Neonatal and Adult Brachial Plexus Injury Models
TLDR
The central and peripheral reactions to nerve injury, the effects of timing of repair on both motor and sensory neuronal survival and basic science evidence to support early intervention are discussed.

References

SHOWING 1-10 OF 76 REFERENCES
Aging of Skeletal Muscle Does Not Affect the Response of Satellite Cells to Denervation
TLDR
It is suggested that aging does not repress the capacity of SC to become activated and grow in the response to muscle denervation.
Satellite cells and the muscle stem cell niche.
TLDR
For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.
Skeletal muscle denervation increases satellite cell susceptibility to apoptosis.
TLDR
The hypothesis that skeletal muscle denervation increases satellite cell susceptibility to apoptotic cell death is tested andApoptosis may play a causative role in the depletion of satellite cells in long-term denervated skeletal muscle.
Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities
TLDR
The purpose of this article is to review the current point of view on the application of stem cell based strategy for peripheral nerve regeneration and highlights studies involving the stem cell types, the mechanisms of their action, methods of delivery to the injury site, and relevant pre-clinical or clinical data.
Peripheral Nerve Injury: Stem Cell Therapy and Peripheral Nerve Transfer
TLDR
This review discusses historical aspects of peripheral nerve injury and introduces nerve transfer as a therapeutic option, as well as an adjunct therapy to transplantation of Schwann cells and their stem cell derivatives for repair of the damaged nerve.
Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles
Interrelations of myogenic response, progressive atrophy of muscle fibers, and cell death in denervated skeletal muscle
TLDR
Investigation of the interrelations between temporal and spatial patterns of the myogenic response in denervated muscle and progressive atrophy of muscle fibers found that the reactivation of myogenesis in the tibialis anterior and extensor digitorum longus muscles of the rat starts before atrophy has attained advanced level, long before dead cells are found in the tissue.
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
TLDR
It is indicated that other cell types with regenerative potential depend on the presence of the satellite cell population, and these observations have important implications for myopathic conditions and stem cell-based therapeutic approaches.
Abortive myogenesis in denervated skeletal muscle: differentiative properties of satellite cells, their migration, and block of terminal differentiation
TLDR
Electron microscopy and immunocytochemical labeling of muscle tissue 1–18 months following denervation demonstrated that despite activation of satellite cells, myogenesis in denervated muscle is abortive and does not lead to the formation of normal muscle fibers.
Differentiation of activated satellite cells in denervated muscle following single fusions in situ and in cell culture
TLDR
Evidence is presented that satellite cells in long-term denervated rat muscle are able to activate synthesis of contractile proteins after single fusions in situ, suggesting that under conditions of denervation, progressive spatial separation and confinement of many satellite cells within the endomysial tubes of atrophic muscle fibers and progressive interstitial fibrosis are the important factors that prevent their normal differentiation.
...
1
2
3
4
5
...