The Role of Multiscale Protein Dynamics in Antigen Presentation and T Lymphocyte Recognition

@inproceedings{Eccleston2017TheRO,
  title={The Role of Multiscale Protein Dynamics in Antigen Presentation and T Lymphocyte Recognition},
  author={Robin Eccleston and Shunzhou Wan and Neil Dalchau and Peter V. Coveney},
  booktitle={Front. Immunol.},
  year={2017}
}
T lymphocytes are stimulated when they recognize short peptides bound to class I proteins of the major histocompatibility complex (MHC) protein, as peptide-MHC complexes. Due to the diversity in T-cell receptor (TCR) molecules together with both the peptides and MHC proteins they bind to, it has been difficult to design vaccines and treatments based on… CONTINUE READING