The Role of Mucus in Cough Research

@article{Rubin2009TheRO,
  title={The Role of Mucus in Cough Research},
  author={Bruce K. Rubin},
  journal={Lung},
  year={2009},
  volume={188},
  pages={69-72}
}
  • B. Rubin
  • Published 2009
  • Medicine, Biology
  • Lung
Cough is a defense mechanism for promoting airway hygiene when mucociliary clearance is ineffective due to increased mucus secretion, inflammation, infection, or ciliary dysfunction. Secretions can contribute to airflow limitation and chronic hypersecretion can worsen airway inflammation with retained inflammatory cells and mediators. The focus of the Second Annual Cough Conference has been on cough as a troublesome symptom; but to understand the importance and effectiveness of cough clearance… 
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16 Citations
Background Citations
2
Results Citations
1

16 Citations

Aerosol Medications for Treatment of Mucus Clearance Disorders
  • B. Rubin
  • Medicine, Biology
    Respiratory Care
  • 2015
TLDR
The pathophysiology of secretory hyper-responsiveness and mucus hypersecretion is reviewed and the different aerosol medications that can be used to augment secretion clearance are discussed.
Airway Clearance and Mucoactive Therapies.
TLDR
The mobilization of secretions must be increased through effective respiratory physiotherapy techniques, which can be manual and/or instrumental, and the properties of mucus can be modified to improve its mobilization through the use of a mucoactive agent.
Airway Clearance Therapy: Finding the Evidence
TLDR
Monitoring and reporting patient, process, and financial outcomes are essential steps germane to the implementation of evidence-based care.
Airway mucus function and dysfunction.
Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review examines the normal…
The use of pulmonary clearance medications in the acutely ill patient
TLDR
The general use of these medications in acutely ill patients without CF cannot be recommended at this time, as the quality of evidence is low, making it difficult to draw conclusions.
Role of Epithelial Cells in Chronic Inflammatory Lung Disease
TLDR
Airborne pathogens entering the lungs first encounter the mucus layer overlaying epithelial cells as a first line of host defense as well as proinflammatory cytokines and chemokines that initiate and amplify host defensive responses to these toxic agents.
Effect of inhaled and oral n-acetylcysteine on airway defense mechanism
TLDR
Chronic administration of oral and inhaled N-acetylcysteine had a negative impact on the ciliary beat frequency, which represents one of the key factors determining the rate of mucociliary clearance and may limit its use in conditions with severe airflow obstruction.
Impact of Hypertonic Saline Solutions on Sputum Expectoration and Their Safety Profile in Patients with Bronchiectasis: A Randomized Crossover Trial.
TLDR
HS and HA+HS were more effective on sputum expectoration than IS in patients with bronchiectasis, reportingHA+HS better safety profile than HS.
Smoking and Lung Inflammation
Smoking and lung inflammation : , Smoking and lung inflammation : , کتابخانه دیجیتال جندی شاپور اهواز
Ex vivo pulmonary assay applied for screening of toxicity potential of chemicals.
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References

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