The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity

@inproceedings{Obst2017TheRO,
  title={The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity},
  author={Juliane Obst and Emilie Simon and Renzo Mancuso and Diego G{\'o}mez-Nicola},
  booktitle={Front. Aging Neurosci.},
  year={2017}
}
Inflammation is a major component of neurodegenerative diseases. Microglia are the innate immune cells in the central nervous system (CNS). In the healthy brain, microglia contribute to tissue homeostasis and regulation of synaptic plasticity. Under disease conditions, they play a key role in the development and maintenance of the neuroinflammatory response, by showing enhanced proliferation and activation. Prion diseases are progressive chronic neurodegenerative disorders associated with the… CONTINUE READING

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