The Role of Methylation in the Intrinsic Dynamics of B- and Z-DNA

Abstract

Methylation of cytosine at the 5-carbon position (5 mC) is observed in both prokaryotes and eukaryotes. In humans, DNA methylation at CpG sites plays an important role in gene regulation and has been implicated in development, gene silencing, and cancer. In addition, the CpG dinucleotide is a known hot spot for pathologic mutations genome-wide. CpG tracts… (More)
DOI: 10.1371/journal.pone.0035558

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