The Role of Memantine in the Treatment of Psychiatric Disorders Other Than the Dementias

  title={The Role of Memantine in the Treatment of Psychiatric Disorders Other Than the Dementias},
  author={G. Sani and G. Serra and G. Kotzalidis and S. Romano and S. Tamorri and G. Manfredi and M. Caloro and C. L. Telesforo and S. Caltagirone and Isabella Panaccione and A. Simonetti and Francesca Demontis and P. Girardi},
  journal={CNS Drugs},
  • G. Sani, G. Serra, +11 authors P. Girardi
  • Published 2012
  • Medicine
  • CNS Drugs
  • Memantine, a non-competitive NMDA receptor antagonist approved for Alzheimer’s disease with a good safety profile, is increasingly being studied in a variety of non-dementia psychiatric disorders. We aimed to critically review relevant literature on the use of the drug in such disorders. We performed a PubMed search of the effects of memantine in animal models of psychiatric disorders and its effects in human studies of specific psychiatric disorders. The bulk of the data relates to the effects… CONTINUE READING
    88 Citations

    Paper Mentions

    The purpose of this research study is to learn if the medication Memantine Hydrochloride (the study medication) can help adolescents and young adults with Down syndrome. Dr. Alberto… Expand
    ConditionsDown Syndrome, Intellectual Disability
    Is Memantine Effective as an NMDA Receptor Antagonist in Adjunctive Therapy for Schizophrenia?
    • 1
    • PDF
    Memantine: New prospective in bipolar disorder treatment.
    • 25
    Memantine: a review of possible uses in child and adolescent psychiatry.
    • Sheik Hosenbocus, Raj Chahal
    • Medicine
    • Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent
    • 2013
    • 42
    • Highly Influenced
    • PDF
    Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions.
    • 10
    • Highly Influenced
    • PDF
    Glutamatergic agents for OCD and related disorders
    • C. Pittenger
    • Psychology, Medicine
    • Current Treatment Options in Psychiatry
    • 2015
    • 29
    • PDF


    A systematic review of off-label uses of memantine for psychiatric disorders
    • 93
    A Randomized, Placebo-Controlled Study of Memantine as Adjunctive Treatment in Patients with Schizophrenia
    • 119
    • PDF
    The role of dopamine in bipolar disorder.
    • 238
    Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence.
    • 105
    • Highly Influential
    The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder.
    • 15
    • PDF
    Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis.
    • 218
    • PDF
    Memantine for the Treatment of Alzheimer’s Disease
    • 65