The Role of Matrix Metalloproteinase 3 and 9 in the Pathogenesis of Acute Neuroinflammation. Implications for Disease Modifying Therapy

@article{Ljubisavljevi2015TheRO,
  title={The Role of Matrix Metalloproteinase 3 and 9 in the Pathogenesis of Acute Neuroinflammation. Implications for Disease Modifying Therapy},
  author={Srdjan Ljubisavljevi{\'c} and Ivana D Stojanovi{\'c} and Jelena T Basic and S Ljiljana Vojinovic and Dragan Stojanov and Gordana Djordjevi{\'c} and Ducica Pavlovic},
  journal={Journal of Molecular Neuroscience},
  year={2015},
  volume={56},
  pages={840-847}
}
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in a variety of physiological and pathological processes, including those in CNS. In this study, plasma values of MMP-3 and MMP-9 have been compared in clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RRMS) patients during their acute attacks, in relation to the biological activity of disease. Therefore, we compared the MMPs plasma values regarding Expanded Disability Status Scale (EDSS… CONTINUE READING
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