The Role of M2000 as an Anti-inflammatory Agent in Toll-Like Receptor 2/microRNA-155 Pathway

@inproceedings{Pourgholi2017TheRO,
  title={The Role of M2000 as an Anti-inflammatory Agent in Toll-Like Receptor 2/microRNA-155 Pathway},
  author={Fatemeh Pourgholi and Mahsa Hajivalili and Rasoul Razavi and Shadi Esmaeili and Behzad Baradaran and Ali Akbar Movasaghpour and Sanam Sadreddini and Hamidreza Goodarzynejad and Abbas Mirshafiey and Mehdi Yousefi},
  booktitle={Avicenna journal of medical biotechnology},
  year={2017}
}
BACKGROUND M2000 is a newly designed and safe Non-Steroidal Anti-Inflammatory Drug (NSAID). The aim of this study was to assess the effects of M2000 on expression levels of Suppressor of Cytokine Signaling-1 (SOCS-1) and Src Homology-2 domain-containing inositol-5'-phosphatase 1 (SHIP1) proteins via Toll-Like Receptor (TLR) 2/microRNA-155 pathway. METHODS HEK293 TLR2 cell line and Peripheral Blood Mononuclear Cells (PBMCs) were treated by different concentrations of M2000 in MTT assay. RNA… CONTINUE READING
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