The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity

  title={The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity},
  author={Sherley Visinoni and Nurul Fathiah Izzati Khalid and Christos N. Joannides and Arthur Shulkes and Mildred Yim and Jon Whitehead and Tony Tiganis and Benjamin J. Lamont and Jenny M. Favaloro and J. Proietto and Sofianos Andrikopoulos and Barbara Christianne Fam},
Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only to regulate glucose or has other metabolic consequences is not clear; therefore, the aim of this study was to determine the importance of liver FBPase in body weight regulation. To this end we performed comprehensive physiologic and biochemical assessments of energy balance in liver-specific transgenic FBPase mice and negative… CONTINUE READING
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