The Role of Lipids in the Control of Autophagy

  title={The Role of Lipids in the Control of Autophagy},
  author={Claudia Dall'Armi and Kelly A. Devereaux and Gilbert Di Paolo},
  journal={Current Biology},
Macroautophagy is an essential cellular pathway mediating the lysosomal degradation of defective organelles, long-lived proteins and a variety of protein aggregates. Similar to other intracellular trafficking pathways, macroautophagy involves a complex sequence of membrane remodeling and trafficking events. These include the biogenesis of autophagosomes, which engulf portions of cytoplasm at specific subcellular locations, and their subsequent maturation into autophagolysosomes through fusion… CONTINUE READING
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