The Role of Interleukin 13 in Classical Hodgkin Lymphoma

  title={The Role of Interleukin 13 in Classical Hodgkin Lymphoma},
  author={Brian F. Skinnider and Ursula Kapp and Tak Wah Mak},
  journal={Leukemia \& Lymphoma},
  pages={1203 - 1210}
The Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) produce several cytokines, which are thought to account for the unique clinical and pathologic features of this disease. We previously identified interleukin (IL)-13 expression as a common feature of cHL and have studied the potential role of this cytokine as an autocrine growth factor for RS cells. IL-13 and the IL-13-specific receptor chain (IL-13R α 1) are frequently expressed in cHL-derived cell lines and in RS cells from… 
The role of interleukin-3 in classical Hodgkin's disease
Evidence is summarized indicating IL-3 as a growth and anti-apoptotic factor for H - RS cells in classical HD through paracrine mechanisms.
Studies on 15-lipoxygenase in dendritic cells and leukotriene receptors in Hodkin lymphoma
This work reports a link between inflammatory cell-derived arachidonic acid metabolites, the cysteinyl leukotrienes (CysLTs), to tumor cell growth and function in this disease entity and demonstrates that calcium ionophore stimulates the translocation of 15-LO-1 to the plasma membrane in human dendritic cells.
CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth
It is reported that CD137 transmits signals into HRS cells, which induce the secretion of IL-13, which facilitates escape from immune surveillance and validates CD137 as a candidate target for immunotherapy of HL.
Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma
Data is presented that link inflammatory cell‐derived arachidonic acid metabolites, the cysteinyl leukotrienes (CysLT), to the pathogenesis of cHL, contributing to the aberrant cytokine network of this lymphoma.
IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis.
Data from experiments using reporter assays and overexpression of constitutively active IKK2 support the hypothesis that the STAT5 and nuclear factor-kappaB (NF-kappB) pathways collaborate in HL genesis.
Cell cycle and apoptosis deregulation in classical Hodgkin lymphomas.
Data is summarized on how the Epstein-Barr Virus, which is present in H/RS cells in about 30-50% of cHL, has been shown to affect the cell cycle and apoptosis regulation in cHL.
IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma.
IL-13 neutralization not only enhances the DTH reaction but also increases longevity and survival of DL-bearing host, which suggests that blocking/inactivating systemic IL- 13 enhances T(h)1 immunity, and therefore, effects to diminish IL-13 production may have therapeutic value in a host bearing T-cell lymphoma.
Serum levels of interleukins 6, 10, and 13 before and after treatment of classic Hodgkin lymphoma.
Serum levels of IL-6 and IL-10 were frequently elevated in patients with HL and decreased substantially after conventional chemotherapy, which suggests those ILs may be useful biomarkers for monitoring the HL disease and its response to chemotherapy.
The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape
This review summarizes updated information on the complex interactions between the HRS cells and their tissue microenvironment and highlights the development of newer therapeutic strategies aimed at targeting the non‐malignant inflammatory/immune cellular components of HL that are involved in cancer cell growth and/or immune escape.


Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Exposure to in situ hybridization of interleukin-13 and IL-13Ralpha1 is a common feature of HRS cells in HL, consistent with the hypothesis that IL- 13 may play a role in autocrine growth in classical HL.
Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
The expression of 950 genes in Hodgkin's disease (HD) is investigated by analyzing differential mRNA expression using microarrays and suggests that IL-13 plays an important role in the stimulation of H/RS cell growth, possibly by an autocrine mechanism.
Interleukin‐13 and interleukin‐13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis
This work investigates the possible involvement of IL‐13 in the pathophysiology of Hodgkin's disease, especially autocrine pathways of H–RS cells, and high expression of interleukin (IL)‐13 was described in HD‐derived cell lines.
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
Immunoblotting and immunohistochemistry results suggest that IL-13 signaling is largely responsible for the constitutive STAT6 activation observed in HRS cells and further implicate IL- 13 as an important growth factor in classical HL.
Differential chemokine expression in tissues involved by Hodgkin's disease: direct correlation of eotaxin expression and tissue eosinophilia.
Evidence of high level chemokine expression in HD tissues is provided and it is suggested that chemokines may play an important role in the recruitment of inflammatory cell infiltrates into tissues involved by HD.
Quantitative immunohistochemical analysis of cytokine profiles in Epstein–Barr virus‐positive and ‐negative cases of Hodgkin's disease
Results suggest that escape from local immune surveillance is not due to a shift from Th1 towards Th2, but may be caused by a direct effect of IL‐10 on the cytotoxic cells.
Recent results on the biology of Hodgkin and Reed-Sternberg cells. I. Biopsy material.
While studies of EBV involvement, growth factor production, oncogene expression and chromosomal abnormalities contributed a fair amount of new data on the nature of H-RS cells, only immunophenotyping and genotyping provided some indication of the cellular derivation.
Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease.
IL-10 expression is frequently associated with EBV-infection in HD and ARL and appears to be upregulated by EBV, most likely through LMP1, in view of the established inhibitory effects of IL-10 on cell mediated immunity.
The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.
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    Laboratory investigation; a journal of technical methods and pathology
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RY-IL-4 blocked the IL-4- andIL-13-mediated vascular cell adhesion molecule (VCAM)-1 expression and Stat6 activation, suggesting that the large number of high-affinity IL-13Ralpha2 monomers are silent receptors, likely representing a decoy target for IL- 13.