The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

@inproceedings{Leroith2011TheRO,
  title={The Role of Insulin and Insulin-like Growth Factors in the Increased Risk
of Cancer in Diabetes},
  author={Derek Leroith and Eyal J. Scheinman and Keren Bitton-Worms},
  booktitle={Rambam Maimonides medical journal},
  year={2011}
}
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to discern the potential mechanistic factors involved in this relationship. Candidates include hyperinsulinemia, insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-2 (IGF-2) signaling. These studies demonstrated that increased… CONTINUE READING

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