The Role of Insulin C-Peptide in the Coevolution Analyses of the Insulin Signaling Pathway: A Hint for Its Functions

@inproceedings{Wang2012TheRO,
  title={The Role of Insulin C-Peptide in the Coevolution Analyses of the Insulin Signaling Pathway: A Hint for Its Functions},
  author={Shuai Wang and Wei Wei and Yadong Zheng and Junling Hou and Yong-xi Dou and Shaohua Zhang and Xue-nong Luo and Xue-peng Cai},
  booktitle={PloS one},
  year={2012}
}
As the linker between the A chain and B chain of proinsulin, C-peptide displays high variability in length and amino acid composition, and has been considered as an inert byproduct of insulin synthesis and processing for many years. Recent studies have suggested that C-peptide can act as a bioactive hormone, exerting various biological effects on the… CONTINUE READING