The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia

@inproceedings{Kumar2011TheRO,
  title={The Role of Inhibition in Generating and Controlling Parkinson’s Disease Oscillations in the Basal Ganglia},
  author={Arvind Kumar and Stefano Cardanobile and Stefan Rotter and Ad Aertsen},
  booktitle={Front. Syst. Neurosci.},
  year={2011}
}
Movement disorders in Parkinson's disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of inhibitory inputs from striatum to globus pallidus external (GPe) is a key parameter controlling oscillations in the basal ganglia. Specifically, the increase in striatal activity observed in PD is… CONTINUE READING