The Role of Inflammatory Mediators in the Mechanism of the Host Immune Response Induced by Ischemia-Reperfusion Injury

@inproceedings{NikbakhtSangari2000TheRO,
  title={The Role of Inflammatory Mediators in the Mechanism of the Host Immune Response Induced by Ischemia-Reperfusion Injury},
  author={Maryam Nikbakht-Sangari and A. Karim Qayumi and Paul Keown},
  year={2000}
}
Our previous study suggested that inflammatory mediators released due to IRI lead to host's immune response by upregulating MHC II in the host's peripheral T lymphocytes. This study hypothesized the role of platelet-activating factor (PAF) in the mechanism of induced MHC II upregulation due to IRI on peripheral T lymphocytes. The objectives of this study were to investigate the role of PAF in the induction of host immune reactivity and the protective effect of PAF-antagonist TCV-309 in… CONTINUE READING