• Corpus ID: 12509575

The Role of Inflammation in Acne Vulgaris

  title={The Role of Inflammation in Acne Vulgaris},
  author={M R Joyce}

Figures from this paper

Study of interleukin‐1 beta expression in acne vulgaris and acne scars

Interleukin‐1 beta (IL‐1β) is a proinflammatory cytokine, suggested to play a key role in acne pathogenesis.

Assessment of serum interleukin‐19 in acne vulgaris patients of different clinical severities

IL-19 is related to the etiopathological inflammatory process of acne vulgaris and correlates with acne severity, and could be proposed as a prognostic inflammatory marker for acne Vulgaris.

Interleukins-6, -8 and -12p40 and C-reactive protein levels in patients with acne vulgaris with various severityof skin changes

Interleukin-6 may be a helpful marker for monitoring the course of the disease and a useful tool for assessing an individual patient’s predisposition to severe skin lesions, and can contribute to faster decision making regarding the introduction of systemic therapy.


A variety of medications are available in the market for the treatment of acne like retinoid derivatives, benzoyl peroxide, and antibiotics etc, among which the topical treatment is most preferred.

The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity

There are differences in serum levels of IL-19 on the severity of acne vulgaris, and the significant difference might show that inflammation has a core role in severity of blush vulgaris.



Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses1

Data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2, which may provide a novel target for treatment of this common skin disease.

Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?

  • C. Zouboulis
  • Biology
    The Journal of investigative dermatology
  • 2009
This commentary summarizes the current knowledge of the association of P. acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that P. Acnes-induced lipids may represent a recruitment of allies and/or enemies of the human skin.

Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris.

The present data further support the involvement of lipid peroxides, in particular squalene peroxide, in establishing an inflammatory process in acne.

Messages from molecules: deciphering the code.

  • J. Weiss
  • Medicine
    Journal of drugs in dermatology : JDD
  • 2013
Gene array analysis of acne lesions has elucidated newer inflammatory mediators that may become future targets for therapeutic development.

Harnessing the anti-inflammatory effects of topical dapsone for management of acne.

  • L. Kircik
  • Medicine, Biology
    Journal of drugs in dermatology : JDD
  • 2010
Data suggest the vehicle formulation enhances healing and contributes to tolerability, making topical dapsone 5% gel a worthwhile anti-inflammatory treatment for many patients with mild-to-moderate acne vulgaris.

Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling.

Gene expression profiling in acne patients indicates a prominent role of matrix metalloproteinases, inflammatory cytokines, and antimicrobial peptides in acne lesions.

Heat‐killed Propionibacterium acnes is capable of inducing inflammatory responses in skin

Killed P. acnes is capable of inducing inflammation in skin suggesting that therapies that have both bactericidal and anti‐inflammatory effects may result in a more effective treatment of patients with acne than treatments that are bactericidal alone.

The SAPHO syndrome.

We report two cases of the SAPHO syndrome (synovitis, acne conglobata, pustulosis palmoplantaris, hyperostosis and osteitis). This syndrome has been published in the pediatric and rheumatological

Cutting Edge: All-trans Retinoic Acid Down-Regulates TLR2 Expression and Function1

Data indicate that ATRA exerts an anti-inflammatory effect on monocytes via two pathways, one specifically affecting TLR2/1 and CD14 expression and one independent of TLR expression.