The Role of IL-17 Signaling in Regulation of the Liver–Brain Axis and Intestinal Permeability in Alcoholic Liver Disease

@article{Ma2016TheRO,
  title={The Role of IL-17 Signaling in Regulation of the Liver–Brain Axis and Intestinal Permeability in Alcoholic Liver Disease},
  author={Hsiao-Yen Ma and Jun Xu and Xiao Lin Liu and Yunheng Zhu and Bin Gao and M. Gilljam Karin and Hidekazu Tsukamoto and Dilip V. Jeste and Igor Grant and Amanda J Roberts and Candice Contet and Cedric G Geoffroy and Binhai Zheng and David Allen Brenner and Tatiana Kisseleva},
  journal={Current Pathobiology Reports},
  year={2016},
  volume={4},
  pages={27-35}
}
Alcoholic liver disease (ALD) progresses from a normal liver, to steatosis, steatohepatitis, fibrosis, and hepatocellular carcinoma (HCC). Despite intensive studies, the pathogenesis of ALD is poorly understood, in part due to a lack of suitable animal models which mimic the stages of ALD progression. Furthermore, the role of IL-17 in ALD has not been evaluated. We and others have recently demonstrated that IL-17 signaling plays a critical role in the development of liver fibrosis and cancer… CONTINUE READING
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