The Role of Hyaluronan Degradation Products as Innate Alloimmune Agonists

@article{Tesar2006TheRO,
  title={The Role of Hyaluronan Degradation Products as Innate Alloimmune Agonists},
  author={Bethany M. Tesar and Dianhua Jiang and J G Liang and Suzette Palmer and Philip W. Noble and Daniel R. Goldstein},
  journal={American Journal of Transplantation},
  year={2006},
  volume={6}
}
Dendritic cells (DCs) play a key role in initiating alloimmunity yet the substances that activate them during the host response to transplantation remain elusive. In this study we examined the potential roles of endogenous innate immune agonists in activating dendritic cell‐dependent alloimmunity. Using a murine in vitro culture system, we show that 135 KDa fragments of the extracellular matrix glycosaminoglycan hyaluronan induce dendritic cell maturation and initiate alloimmunity. Priming of… Expand
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