The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

@article{Laizure2013TheRO,
  title={The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?},
  author={S. Casey Laizure and V. Herring and Zheyi Hu and Kevin Witbrodt and R. B. Parker},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2013},
  volume={33}
}
Carboxylesterases are a multigene family of mammalian enzymes widely distributed throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and carbamates. In humans, two carboxylesterases, hCE1 and hCE2, are important mediators of drug metabolism. Both are expressed in the liver, but hCE1 greatly exceeds hCE2. In the intestine, only hCE2 is present and highly expressed. The most common drug substrates of these enzymes are ester prodrugs specifically designed to enhance… Expand
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