The Role of Hklp2 in the Stabilization and Maintenance of Spindle Bipolarity

  title={The Role of Hklp2 in the Stabilization and Maintenance of Spindle Bipolarity},
  author={David Vanneste and Masatoshi Takagi and Naoko Imamoto and Isabelle Vernos},
  journal={Current Biology},
Spindle bipolarity relies on a fine balance of forces exerted by various molecular motors [1-4]. In most animal cells, spindle bipolarity requires sustained outward forces to push the spindle poles apart, an activity that is provided by Eg5, a conserved homotetrameric plus-end-directed kinesin that crosslinks and slides antiparallel microtubules apart [5]. These pushing forces are balanced by inward minus-end-directed forces. Impairing both Eg5 and dynein restores the formation of functional… CONTINUE READING
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