The Role of Heparanase in Diseases of the Glomeruli

@article{Szymczak2009TheRO,
  title={The Role of Heparanase in Diseases of the Glomeruli},
  author={Maciej Szymczak and Jakub Kuźniar and Marian Klinger},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
  year={2009},
  volume={58},
  pages={45-56}
}
The glomerular basement membrane (GBM) is a kind of net that remains in a state of dynamic equilibrium. Heparan sulfate proteoglycans (HSPGs) are among its most important components. There are much data indicating the significance of these proteoglycans in protecting proteins such as albumins from penetrating to the urine, although some new data indicate that loss of proteoglycans does not always lead to proteinuria. Heparanase is an enzyme which cleaves β 1,4 d-glucuronic bonds in sugar groups… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

The advancements of heparanase in fibrosis.

International journal of molecular epidemiology and genetics • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 141 references

Increased expression of heparanase in overt diabetic nephropathy

MJ van den Hoven, AL Rops, MA Bakker
Kidney Int • 2006
View 6 Excerpts
Highly Influenced

Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88).

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis • 2001
View 7 Excerpts
Highly Influenced

A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis.

Journal of the American Society of Nephrology : JASN • 2004
View 20 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…