The Role of Heparanase in Diseases of the Glomeruli

  title={The Role of Heparanase in Diseases of the Glomeruli},
  author={Maciej Szymczak and Jakub Kuźniar and Marian Klinger},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
The glomerular basement membrane (GBM) is a kind of net that remains in a state of dynamic equilibrium. Heparan sulfate proteoglycans (HSPGs) are among its most important components. There are much data indicating the significance of these proteoglycans in protecting proteins such as albumins from penetrating to the urine, although some new data indicate that loss of proteoglycans does not always lead to proteinuria. Heparanase is an enzyme which cleaves β 1,4 d-glucuronic bonds in sugar groups… CONTINUE READING


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