The Role of Glial Adenosine Receptors in Neural Resilience and the Neurobiology of Mood Disorders

  title={The Role of Glial Adenosine Receptors in Neural Resilience and the Neurobiology of Mood Disorders},
  author={Dietrich van Calker and Knut Biber},
  journal={Neurochemical Research},
Adenosine receptors were classified into A1- and A2-receptors in the laboratory of Bernd Hamprecht more than 25 years ago. Adenosine receptors are instrumental to the neurotrophic effects of glia cells. Both microglia and astrocytes release after stimulation via adenosine receptors factors that are important for neuronal survival and growth. Neuronal resilience is now considered as of pivotal importance in the neurobiology of mood disorders and their treatment. Both sleep deprivation and… CONTINUE READING


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