The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.

@article{Howes2017TheRO,
  title={The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.},
  author={Oliver D. Howes and Robert T. McCutcheon and Michael J Owen and Robin MacGregor Murray},
  journal={Biological psychiatry},
  year={2017},
  volume={81 1},
  pages={9-20}
}
The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia. Because it was initially based on indirect evidence and findings in patients with established schizophrenia, it was unclear what role dopamine played in the onset of the disorder. However, recent studies in people at risk of schizophrenia have found elevated striatal dopamine synthesis capacity and increased dopamine release to stress. Furthermore, striatal dopamine changes have been linked to altered… CONTINUE READING