The Role of Functional Neuroimaging in the Choice of Treatment for Alcoholics

Abstract

neuroimmune genes consistent with ethanol-induced neuroinflammation. In brain slice cultures, exogenous IL-1beta, TNFalpha and MCP1 reduce neurogenesis. Neutralizing antibodies to IL-1beta added to slice cultures increased neurogenesis and completely reversed ethanol inhibiton of neurogenesis. Exogenous IL-1 receptor antagonist, IL-1RIa, also blocked ethanol inhibition of neurogenesis, suggesting that IL-1beta mediates ethanol inhibition of neurogenesis. A number of drugs reverse ethanol inhibition of neurogenesis. Antidressants that are effective treatments of human depression reverse ethanol induction of IL1beta and stimulate neurogenesis. Drugs that blunt neuroimmune activation, block inflammasome formation or NFkappaB activation reverse ethanol inhibition of neurogenesis. These findings suggest that inflammasome induction and loss of neurogenesis contribute depression and negative affect. Antidepressants and anti-neuroinflammatory drugs reverse ethanol inhibition of neurogenesis through inhibition of IL-1beta. (This study was supported by NIH and NIAAA.)

Cite this paper

@inproceedings{Mann2011TheRO, title={The Role of Functional Neuroimaging in the Choice of Treatment for Alcoholics}, author={K. Mann and Matth{\"a}us Willeit}, year={2011} }