The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice.

@article{Chevalier2016TheRO,
  title={The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice.},
  author={Nina Chevalier and Laurence M Macia and Jian Kai Tan and Linda J. Mason and Remy Robert and Alison N. Thorburn and Connie H Y Wong and Louis M. Tsai and Katherine Bourne and Robert Brink and Di Yu and Charles R Mackay},
  journal={Arthritis & rheumatology},
  year={2016},
  volume={68 4},
  pages={1026-38}
}
OBJECTIVE Antibody-mediated autoimmunity involves cognate interactions between self-reactive T cells and B cells during germinal center (GC) reactions. The aim of this study was to determine the role of essential follicular helper T (Tfh) cell molecules (CXCR5, signaling lymphocytic activation molecule-associated protein) on autoreactive CD4+ cells and the role of certain environmental influences that may determine GC-driven autoantibody production and arthritis development. METHODS We… CONTINUE READING