The Role of External and Matrix pH in Mitochondrial Reactive Oxygen Species Generation*

@article{Selivanov2008TheRO,
  title={The Role of External and Matrix pH in Mitochondrial Reactive Oxygen
 Species
 Generation*},
  author={Vitaly A. Selivanov and Jennifer Zeak and Josep Roca and Marta Cascante and Massimo Trucco and Tatyana V. Votyakova},
  journal={The Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={29292 - 29300}
}
Reactive oxygen species (ROS) generation in mitochondria as a side product of electron and proton transport through the inner membrane is important for normal cell operation as well as development of pathology. Matrix and cytosol alkalization stabilizes semiquinone radical, a potential superoxide producer, and we hypothesized that proton deficiency under the excess of electron donors enhances reactive oxygen species generation. We tested this hypothesis by measuring pH dependence of reactive… CONTINUE READING
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