The Role of Endothelin in the Pathophysiology of Migraine—a Systematic Review

@article{Iljazi2018TheRO,
  title={The Role of Endothelin in the Pathophysiology of Migraine—a Systematic Review},
  author={Afrim Iljazi and Cenk Ayata and Messoud Ashina and Anders Hougaard},
  journal={Current Pain and Headache Reports},
  year={2018},
  volume={22},
  pages={1-9}
}
Purpose of ReviewVasoactive peptides play a key role in the attack-initiating cascade of migraine. Recent studies have highlighted a potentially important role for endothelin-1, a potent vasoconstrictor peptide, in migraine pathophysiology. Here, we review the current data on endothelin’s involvement in migraine.Recent FindingsWe identified 23 articles. Nine studies reported on endothelin-1 plasma concentrations in patients with migraine, eight studies investigated relevant genetic associations… Expand
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