The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis

Abstract

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing… (More)
DOI: 10.1007/s00005-014-0310-1

Topics

4 Figures and Tables

Slides referencing similar topics