The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans.

@article{BrunerTran2012TheRO,
  title={The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans.},
  author={Kaylon L. Bruner-Tran and David Resuehr and Tianbing Ding and John A Lucas and Kevin G. Osteen},
  journal={Current obstetrics and gynecology reports},
  year={2012},
  volume={1 3},
  pages={116-123}
}
In a murine model, we have linked early life toxicant exposure to reduced uterine sensitivity to progesterone, a phenotype we had previously associated with inflammation in endometriosis patients. Subsequent studies revealed that developmental toxicant exposure not only reduces fertility in male and female mice but also negatively impacts pregnancy leading to spontaneous preterm birth (PTB). An epigenetic alteration of the progesterone receptor gene correlated with reduced fertility and adverse… CONTINUE READING

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