The Role of Efflux and Physiological Adaptation in Biofilm Tolerance and Resistance.


Microbial biofilms demonstrate a decreased susceptibility to antimicrobial agents. Various mechanisms have been proposed to be involved in this recalcitrance. We focus on two of these factors. Firstly, the ability of sessile cells to actively mediate efflux of antimicrobial compounds has a profound impact on resistance and tolerance, and several studies… (More)
DOI: 10.1074/jbc.R115.707257


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