The Role of E-Cadherin-Catenin Complex in Prostate Cancer Progression

@inproceedings{Murali2013TheRO,
  title={The Role of E-Cadherin-Catenin Complex in Prostate Cancer Progression},
  author={Anuradha Kudur Murali and James K S Norris},
  year={2013}
}
The genetic changes that promote progression of prostate adenocarcinomas are multifactori‐ al and include alterations in several genes. The aberrations include those in genes that affect normal cell adhesion. The long arm of chromosome 16 (16q22.1) is deleted in 30% of primary prostatic tumors and more than 70% of metastatic prostate cancers. The E-cadherin gene is located in this region. E-cadherin is involved in maintaining homotypic cell-cell adhesion between normal prostatic glandular cells… CONTINUE READING

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