The Role of Dipeptidyl Peptidase IV (DP IV) Enzymatic Activity in T Cell Activation and Autoimmunity

@inproceedings{Reinhold2002TheRO,
  title={The Role of Dipeptidyl Peptidase IV (DP IV) Enzymatic Activity in T Cell Activation and Autoimmunity},
  author={Dirk Reinhold and Thilo K{\"a}hne and Andreas Steinbrecher and Sabine Wrenger and Klaus Neubert and Siegfried Ansorge and Stefan Brocke},
  booktitle={Biological chemistry},
  year={2002}
}
Abstract Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as… Expand
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TLDR
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TLDR
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The presented data provide evidence that DP IV is expressed on human sebocytes and most likely involved in regulation of sebocyte proliferation and cytokine production. The aminopeptidase inhibitorsExpand
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TLDR
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