The Role of Diazepam in the Treatment of Nerve Agent Poisoning in a Civilian Population

  title={The Role of Diazepam in the Treatment of Nerve Agent Poisoning in a Civilian Population},
  author={Timothy Clive Marrs},
  journal={Toxicological Reviews},
  • T. Marrs
  • Published 2004
  • Medicine, Biology, Psychology
  • Toxicological Reviews
The main site of action of diazepam, as with other benzodiazepines, is at the GABAA receptor, although it has been suggested that some of the potentially beneficial actions of diazepam in nerve agent poisoning are mediated through other means. It is likely that convulsions may have long-term sequelae in the central nervous system, because of damage by anoxia and/or excitotoxicity. Numerous pharmacodynamic studies of the action of diazepam in animals experimentally poisoned with nerve agents… 
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