The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration 1

@inproceedings{Uchiyama2012TheRO,
  title={The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration 1},
  author={Yasuo Uchiyama},
  year={2012}
}
Cellular DNA is constantly being damaged not only by extrinsic factors such as ionizing radiation and environmental carcinogens but also by intrinsic agents such as reactive oxygen species arising during normal cellular metabolism. Of the myriad of DNA lesions, inflicted by extrinsic and intrinsic genome damaging agents, DNA double strand break (DSB) is the most threatening. Replication fork arrest at DNA lesions could also be a threat since stalled replication forks, if fail to restart… CONTINUE READING

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