The Role of DNA Looping in the Search for Specific Targets on DNA by Multisite Proteins.

@article{Shvets2016TheRO,
  title={The Role of DNA Looping in the Search for Specific Targets on DNA by Multisite Proteins.},
  author={Alexey A. Shvets and Anatoly B Kolomeisky},
  journal={The journal of physical chemistry letters},
  year={2016},
  volume={7 24},
  pages={
          5022-5027
        }
}
Many cellular processes involve simultaneous interactions between DNA and protein molecules at several locations. They are regulated and controlled by special protein-DNA complexes, which are known as synaptic complexes or synaptosomes. Because of the multisite nature of involved proteins, it was suggested that during the formation of synaptic complexes DNA loops might appear, but their role is unclear. We developed a theoretical model that allowed us to evaluate the effect of transient DNA… CONTINUE READING
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