The Role of DNA Double-Strand Breaks in Spontaneous Homologous Recombination in S. cerevisiae

Abstract

Homologous recombination (HR) is a source of genomic instability and the loss of heterozygosity in mitotic cells. Since these events pose a severe health risk, it is important to understand the molecular events that cause spontaneous HR. In eukaryotes, high levels of HR are a normal feature of meiosis and result from the induction of a large number of DNA… (More)

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