The Role of Copper in Tumour Angiogenesis

@article{Lowndes2006TheRO,
  title={The Role of Copper in Tumour Angiogenesis},
  author={S. Lowndes and A. Harris},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2006},
  volume={10},
  pages={299-310}
}
  • S. Lowndes, A. Harris
  • Published 2006
  • Biology, Medicine
  • Journal of Mammary Gland Biology and Neoplasia
  • Copper stimulates the proliferation and migration of endothelial cells and is required for the secretion of several angiogenic factors by tumour cells. Copper chelation decreases the secretion of many of these factors. Serum copper levels are upregulated in many human tumours and correlate with tumour burden and prognosis. Copper chelators reduce tumour growth and microvascular density in animal models. New orally active copper chelators have enabled clinical trials to be undertaken, and there… CONTINUE READING
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