• Corpus ID: 7906579

The Role of Coenzyme Q 10 in Clinical Medicine: Part I

  title={The Role of Coenzyme Q 10 in Clinical Medicine: Part I},
  author={Alan R. Gaby},
This review discusses the potential role of coenzyme Q10 in the treatment of acquired immunodeficiency syndrome (AIDS), cancer, periodontal disease, gastric ulceration, obesity, muscular dystrophy, and allergy. The effect of coenzyme Q10 (CoQ10) on immune function and physical performance is also reviewed. Controlled trials have demonstrated a beneficial effect of CoQ10 in the treatment of periodontal disease. Promising (although anecdotal) clinical results have been reported for cases of… 

Virtue of Coenzyme Q10 as an Antioxidant Drug in Periodontal Disease : A Review

Evidence of beneficial effect in cardiovascular and neuro degenerative disease were noted and it was found that Q10 has superior safety record and the relation of CoQ10 to the periodontal disease is given.

Coenzyme Q and Its Role in the Dietary Therapy against Aging

The present review focuses on the current knowledge and evidence the roles of CoQ cells, its relationship with aging, and possible implications of dietary CoQ in relation to aging, lifespan or age-related diseases.

Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases

Ubiquinol (reduced form coenzyme Q10) serves as an endogenous antioxidant which increases the concentration of CoQ10 in the diseased gingiva and effectively suppresses advanced periodontal inflammation.

A clinical and microbiological study to evaluate the effect of dietary supplement of coenzyme Q10 in nonsurgical treatment outcome of chronic periodontitis patients after phase 1 periodontal therapy

Long-term regular intake of nutritional dietary supplement of CoQ10 is more beneficial in nonsurgical treatment outcome of periodontal disease.

Enhancing Mitochondrial Function With D-Ribose

The use of D-ribose (often shortened to ribose) to help mitochondria work properly is discussed and how practitioners can use this information to dramatically help their fatigue, pain, and cardiac patients feel better is explained.

An investigation of oxidative stress and coenzyme Q10 levels in patients with head and neck squamous cell carcinomas

In HNSCC patients, lipo-oxidative damage increased while nitrosative stress did not change; however, antioxidant activity decreased which in turn increased both lipid peroxidation and oxidative stress.

Clinical evaluation of topical application of perio-Q gel (Coenzyme Q10) in chronic periodontitis patients

In chronic periodontitis patients, sub-gingival mechanical debridement only and with Perio-Q gel showed almost similar clinical results without any statistically significant differences, which confirmed the primary role of basic mechanical approaches in periodontal therapy and did not provide enough clinical support for the superiority of adjunctive use of Perio -Q gel.

Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases

In vitro studies indicate that possible mechanisms by which these compounds might exert their protective effects include antioxidative properties, oxygen and nitrogen scavenging abilities, and also inhibitory effects on cell signaling cascades related to inflammatory processes which have an effect on RNS or ROS production as well as on antioxidant defense systems.

JCN1604_Article 2

  • Biology
  • 2002
It is concluded that ubiquinol-10 protected LDL-cholesterol more efficiently against lipid peroxidation than did vitamin E, suggesting that Coenzyme Q10 and Cardiovascular Disease: A Review has important clinical implications.


Chemical and physical properties. Ubiquinone, chemically is 2,3-dimethoxy-5-methyl-6-polyisoprene parabenzoquinone .It is in its natural form an orange lipophile powder,without odour and taste.



Bioenergetics in clinical medicine. II. Adjunctive treatment with coenzyme Q in periodontal therapy.

Treatment of periodontitis with coenzyme Q should be considered as adjunctive treatment with current dental practice and could correlate with the extraordinarily healing.

Bioenergetics in clinical medicine. IX. Gingival and leucocytic deficiencies of coenzyme Q10 in patients with periodontal disease.

The results support previously suggested adjunctive use of CoQ10 with oral hygiene for improved treatment presumably through bioenergetics and indicate a systemic nutritional imbalance and is not likely caused by neglected oral hygiene.

Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment.

Deficiency of coenzyme Q 10 in gingival tissue from patients with periodontal disease.

These data correlate with clinical studies in Japan that have indicated a therapeutic benefit of the administration of coenzyme Q(7) to many patients with severe and destructive periodontal disease and with the benefit of administration of hexahydrocoenzymeQ(4) to one such patient in the current work.

Biochemical rationale and the cardiac response of patients with muscle disease to therapy with coenzyme Q10.

The results indicate that the impaired myocardial function of such patients with muscular disease may have some association with impaired function of skeletal muscle, both of which may be improved by CoQ10 therapy.

Study of CoQ10-enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10.

The specific activities of both the succinate dehydrogenase-coenzyme Q(10) reductase and the DPNH-cytochrome c reductases were determined in mitochondria from 40 diseased gingival biopsies from patients with periodontal disease and from 24 control tissues from nondiseased areas.

Bioenergetics in clinical medicine. VI. adjunctive treatment of periodontal disease with coenzyme Q10.

Pocket-depth, periodontal health, calculus and plaque scores provided the most valuable data for evaluation.