The Role of Chromosome Domains in Shaping the Functional Genome

Abstract

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible to the transcriptional machinery to allow appropriate expression of genes in different cell types and throughout developmental pathways. A growing body of work has shown that the genome, analogously to proteins, forms an ordered, hierarchical structure that closely… (More)
DOI: 10.1016/j.cell.2015.02.040

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