The Role of Cdk5 in Alzheimer’s Disease

@article{Liu2015TheRO,
  title={The Role of Cdk5 in Alzheimer’s Disease},
  author={Shu-Lei Liu and Chong Wang and Teng Jiang and Lan Tan and Ang Xing and Jin-Tai Yu},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={4328-4342}
}
Alzheimer’s disease (AD) is known as the most fatal chronic neurodegenerative disease in adults along with progressive loss of memory and other cognitive function disorders. Cyclin-dependent kinase 5 (Cdk5), a unique member of the cyclin-dependent kinases (Cdks), is reported to intimately associate with the process of the pathogenesis of AD. Cdk5 is of vital importance in the development of CNS and neuron movements such as neuronal migration and differentiation, synaptic functions, and memory… 
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