The Role of Caspase-3 Activation in Phencyclidine-Induced Neuronal Death in Postnatal Rats

@article{Wang2007TheRO,
  title={The Role of Caspase-3 Activation in Phencyclidine-Induced Neuronal Death in Postnatal Rats},
  author={Cheng Z. Wang and Kenneth M. Johnson},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={1178-1194}
}
This study determined the role of caspase-3 in phencyclidine (PCP)-induced neurodegeneration in postnatal rats. PCP administration to postnatal day 7 rats induced a dose-dependent increase in caspase-3 enzymatic activity in frontal cortex, striatum, and hippocampus. Enzymatic activation was present at 4 h, peaked between 6 and 12 h, and disappeared by 24 h. Further, cleaved caspase-3-immunoreactive neurons were detected as early as 2 h in the cortex, and were found throughout the brain… CONTINUE READING

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