The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

@inproceedings{Zheng2014TheRO,
  title={The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity},
  author={Fang Zheng and Kevin D. Phelan},
  booktitle={Cells},
  year={2014}
}
Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an increase in intracellular free Ca2+ concentration. Thus, activation of TRPC channels could be a common downstream event of many signaling pathways that contribute to seizure and… CONTINUE READING

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