The Role of CSF-1 in Normal Physiology of Mammary Gland and Breast Cancer: An Update

  title={The Role of CSF-1 in Normal Physiology of Mammary Gland and Breast Cancer: An Update},
  author={E. Sapi},
  journal={Experimental Biology and Medicine},
  pages={1 - 11}
  • E. Sapi
  • Published 2004
  • Biology, Medicine
  • Experimental Biology and Medicine
  • Colony stimulating factor (CSF-1) and its receptor (CSF-1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. However, studies have demonstrated that CSF-1 and CSF-1R have additional roles in mammary gland development during pregnancy and lactation. This apparent role for CSF-1/CSF-1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be… CONTINUE READING
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